Selected Publications

(for more publications, please refer to PubMed)

Sahu, I., Mali, S. M., Sulkshane, P., Xu, C., Rozenberg, A., Morag, R., Sahoo, M. P., Singh, S. K., Ding, Z., Wang, Y., Day, S., Cong, Y., Kleifeld, O.*, Brik, A.* & Glickman, M. H.* The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag. Nature Communications 2021 12:1 12, 1–21 (2021).

Boughton, A. J., Liu, L., Lavy, T., Kleifeld, O. & Fushman, D. A novel recognition site for polyubiquitin and ubiquitin-like signals in an unexpected region of proteasomal subunit Rpn1. Journal of Biological Chemistry 297, 101052 (2021).

C. Huang, C. Lewis, N.A. Borg, M. Canals, H. Diep, G. Drummond, R.J. Goode, R.B. Schittenhelm, A. Vinh, M. Zhu, B. Kemp-Harper*, O. Kleifeld*, M.J. Stone*, Proteomic Identification of Interferon-induced Proteins with Tetratricopeptide Repeats (IFITs) as Markers of M1 Macrophage Polarization, J. Proteome Res. (2018) acs.jproteome.7b00828. doi:10.1021/acs.jproteome.7b00828.

R. Meledin, S. Mali, O. Kleifeld*, A. Brik* Activity-Based Probes Developed by Applying Sequential Dehydroalanine Strategy on Expressed Proteins Reveal a Potential α-globin Modulating Deubiquitinase, Angew. Chemie Int. Ed. (2018). doi:10.1002/anie.201800032.

A.L. Samson, B. Ho, A.E. Au, S.M. Schoenwaelder, M.J. Smyth, S.P. Bottomley, O. Kleifeld*, R.L. Medcalf*, Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells, Open Biol. 6 (2016) 160098. doi:10.1098/rsob.160098.

S.K. Singh, I. Sahu, S.M. Mali, H.P. Hemantha, O. Kleifeld, M.H. Glickman, A. Brik, Synthetic Uncleavable Ubiquitinated Proteins Dissect Proteasome Deubiquitination and Degradation, and Highlight Distinctive Fate of Tetraubiquitin, J. Am. Chem. Soc. 138 (2016) 16004–16015. doi:10.1021/jacs.6b09611.

M.A. Rees, T.P. Stinear, R.J.A. Goode, R.L. Coppel, A.I. Smith, O. Kleifeld, Changes in protein abundance are observed in bacterial isolates from a natural host, Front. Cell. Infect. Microbiol. 5 (2015) 71. doi:10.3389/fcimb.2015.00071.

I. Ziv, Y. Matiuhin, D.S. Kirkpatrick, Z. Erpapazoglou, S. Leon, M. Pantazopoulou, W. Kim, S.P. Gygi, R. Haguenauer-Tsapis, N. Reis, M.H. Glickman*, O. Kleifeld*, A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis., Mol. Cell. Proteomics. 10 (2011) M111.009753.

O. Kleifeld, A. Doucet, U. auf dem Keller, A. Prudova, O. Schilling, R.K. Kainthan, A.E. Starr, L.J. Foster, J.N. Kizhakkedathu, C.M. Overall, Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products., Nat. Biotechnol. 28 (2010) 281–8.

  • Equal contribution by last and corresponding authors