Selected Publications
(for more publications, please refer to PubMed)
Sahoo, M.P., Lavy, T., Sahu, I., Kleifeld, O. Activity-Guided Proteomic Profiling of Proteasomes Uncovers a Variety of Active (And Inactive) Proteasome Species BioRxiv, April 2023
Hanna, R., Rozenberg, A., Ben-Yosef, D., Lavy, T., Kleifeld, O. In-Depth Characterization of Apoptosis N-Terminome Reveals a Link Between Caspase-3 Cleavage and Post-Translational N-Terminal Acetylation. Molecular and Cellular Proteomics (2023), 100584.
Roitman, S., Rozenberg A., Lavy, T., Brussaard, C.P.D., Kleifeld, O. & Béjà, O. Isolation and infection cycle of a polinton-like virus virophage in an abundant marine alga. Nature Microbiology 8(2), 332-346. (2023).
Zananiri, R., Venkata, S.M., Gaydar, V., Yahalom, D., Malik, O., Rudnizky, S., Kleifeld, O., A Kaplan, A*. & Henn, A.* Auxiliary ATP binding sites support DNA unwinding by RecBCD. Nature Communications 13, Article number: 1806 (2022).
Sahu, I., Mali, S. M., Sulkshane, P., Xu, C., Rozenberg, A., Morag, R., Sahoo, M. P., Singh, S. K., Ding, Z., Wang, Y., Day, S., Cong, Y., Kleifeld, O.*, Brik, A.* & Glickman, M. H.* The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag. Nature Communications 2021 12, 1–21 (2021).
Boughton, A. J., Liu, L., Lavy, T., Kleifeld, O. & Fushman, D. A novel recognition site for polyubiquitin and ubiquitin-like signals in an unexpected region of proteasomal subunit Rpn1. Journal of Biological Chemistry 297, 101052 (2021).
C. Huang, C. Lewis, N.A. Borg, M. Canals, H. Diep, G. Drummond, R.J. Goode, R.B. Schittenhelm, A. Vinh, M. Zhu, B. Kemp-Harper*, O. Kleifeld*, M.J. Stone*, Proteomic Identification of Interferon-induced Proteins with Tetratricopeptide Repeats (IFITs) as Markers of M1 Macrophage Polarization, Journal of Proteome Research (2018) 17, 1485–1499 (2018).
R. Meledin, S. Mali, O. Kleifeld*, A. Brik* Activity-Based Probes Developed by Applying Sequential Dehydroalanine Strategy on Expressed Proteins Reveal a Potential α-globin Modulating Deubiquitinase. Angewandte Chemie – International Edition 57, 5645–5649 (2018).
A.L. Samson, B. Ho, A.E. Au, S.M. Schoenwaelder, M.J. Smyth, S.P. Bottomley, O. Kleifeld*, R.L. Medcalf*, Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells, Open Biology 6 (2016) 160098. doi:10.1098/rsob.160098.
S.K. Singh, I. Sahu, S.M. Mali, H.P. Hemantha, O. Kleifeld, M.H. Glickman, A. Brik, Synthetic Uncleavable Ubiquitinated Proteins Dissect Proteasome Deubiquitination and Degradation, and Highlight Distinctive Fate of Tetraubiquitin, J. Am. Chem. Soc. 138 (2016) 16004–16015. doi:10.1021/jacs.6b09611.
M.A. Rees, T.P. Stinear, R.J.A. Goode, R.L. Coppel, A.I. Smith, O. Kleifeld, Changes in protein abundance are observed in bacterial isolates from a natural host, Front. Cell. Infect. Microbiol. 5 (2015) 71. doi:10.3389/fcimb.2015.00071.
I. Ziv, Y. Matiuhin, D.S. Kirkpatrick, Z. Erpapazoglou, S. Leon, M. Pantazopoulou, W. Kim, S.P. Gygi, R. Haguenauer-Tsapis, N. Reis, M.H. Glickman*, O. Kleifeld*, A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis., Molecular and Cellular Proteomics. 10 (2011) M111.009753.
O. Kleifeld, A. Doucet, U. auf dem Keller, A. Prudova, O. Schilling, R.K. Kainthan, A.E. Starr, L.J. Foster, J.N. Kizhakkedathu, C.M. Overall, Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products., Nature Biotechnology. 28 (2010) 281–8.
- Equal contribution by last and corresponding authors